In total, 1835 cases with the following criteria were selected: valid results from both the multiprobe FISH assay and urine cytology in the same urine sample, histologic and/or cystoscopic follow-up within 4 months of the original tests, or at least 3 years of clinical follow-up information. For this study, the authors evaluated the effectiveness of multiprobe FISH and urine cytology in detecting urothelial cell carcinoma (UCC) in the same urine sample.
UroVysion is a multiprobe fluorescence in situ hybridization (FISH) assay that detects common chromosome abnormalities in bladder cancers. Urine cytology has been used for screening of bladder cancer but has been limited by its low sensitivity. Therefore, this method has a higher sensitivity than the conventional C method as the sensitivity of urine cytology tests relies partially on the number of cells visualized in the prepared samples.Įvaluation of urovysion and cytology for bladder cancer detection: a study of 1835 paired urine samples with clinical and histologic correlation.ĭimashkieh, Haythem Wolff, Daynna J Smith, T Michael Houser, Patricia M Nietert, Paul J Yang, Jack After introduction of the F method, the number of f alse negative cases was decreased in the urine cytology test because a larger number of cells was seen and easily detected as atypical or malignant epithelial cells. The number of cells on the glass slides prepared by the F method was significantly higher than that of the samples prepared by the C method (p＜0.001).
When the samples included in category 4 or 5, were defined as cytological positive, the sensitivities of this test with samples prepared using the F method were significantly high compared with samples prepared using the C method (72% vs 28%, p＜0.001). From January 2012 to June 2013, 2,031 urine samples were prepared using the conventional centrifuge method (C method) and from September 2013 to March 2015, 2,453 urine samples were prepared using the filtration method (F method) for the cytology test. The differences in the cytodiagnosis between the two methods are discussed here. In our laboratory, we were able to attain a high sensitivity of urine cytology tests after changing the preparation method of urine samples. However, the sensitivity of this test is not high enough to screen for malignant cells. This test is also of great value for predicting malignancy. The urine cytology test is one of the most important tools for the diagnosis of malignant urinary tract tumors. Sekita, Nobuyuki Shimosakai, Hirofumi Nishikawa, Rika Sato, Hiroaki Kouno, Hiroyoshi Fujimura, Masaaki Mikami, Kazuo It is often done when blood is seen in the urine. The test is done to detect cancer of the urinary tract. Urine cytology Bladder cancer - cytology Urethral cancer - cytology Renal cancer - cytology.
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